Dr. Adam Carie (second from right), shown with his committee following his dissertation defense. Pictured from left to right: Dissertation Chair Adrienne Cox, UNC-Chapel Hill, Committee members Hong-Gang Wang, Noreen Luetteke and Srikumar Chellappan; Adam and Major Professor Said Sebti. Dr. Carie has a new title with Intezyne Techonologies; he is now Manager, Formulation Development.
Adam has the distinction of being the first graduate from the Program to be named as a Commencement speaker for Spring 2008 graduation.
Dr. Carie's publication record while in the Program:
Sun J, Wang DA, Jain RK, Carie A, Paquette S, Ennis E, Blaskovich MA, Baldini L, Coppola D, Hamilton AD, Sebti SM. Inhibiting angiogenesis and tumorigenesis by synthetic molecule that blocks binding of both VEGF and PDGF to their receptors. Oncogene. 2005 Jul 7;24(29):4701-9.
Zhou H, Wang D, Baldini L, Ennis E, Jain R, Carie A, Sebti S, Hamilton A. Structure-activity studies on a library of potent calyxarene-based antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Org Biomol Chem. 2006 Jun 21;4(12):2376-86. Epub 2006 May 10.
Carie A, Sebti S. A Chemical Biology Approach Identifies a Beta 2 Andrenergic Receptor Agonist that Causes Human Tumor Regression by Blocking the Raf-1/Mek/Erk1/2 Pathway. Oncogene. 2007 May 31;26(26):3777-88. Epub 2007 Jan 29.
Kinkade R, Dasgupta P, Carie A, Pernazza D, Carless M, Pillai S, Lawrence N, Sebti S, Chellappan S. A small molecule disruptor of Rb-Raf-1 interaction inhibits cell proliferation, angiogenesis and growth of human tumor xenografts in nude mice. Cancer Res. 2008 May 15;68(10):3810-8.
Kazi A, Carie A, Blaskovich MA, Bucher C, Thai V, Moulder S, Peng H, Carrico D, Pusateri E, Pledger WJ, Berndt N, Hamilton A, Sebti SM.Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Mol Cell Biol. 2009 Apr;29(8):2254-63.
Dr. Carie's publication record since graduation:
Barkey NM, Preihs C, Cornnell HH, Martinez G, Carie A, Vagner J, Xu L, Lloyd MC, Lynch VM, Hruby VJ, Sessler JL, Sill KN, Gillies RJ, Morse DL. Development and in vivo quantitative magnetic resonance imaging of polymer micelles targeted to the melanocortin 1 receptor. J Med Chem. 2013 Aug 22;56(16):6330-8. PMID: 23863078
Rios-Doria J, Carie A, Costich T, Burke B, Skaff H, Panicucci R, Sill K.A versatile polymer micelle drug delivery system for encapsulation and in vivo stabilization of hydrophobic anticancer drugs. J Drug Deliv. 2012;2012:951741. PMID: 22518317
Carie A, Rios-Doria J, Costich T, Burke B, Slama R, Skaff H, Sill K. IT-141, a Polymer Micelle Encapsulating SN-38, Induces Tumor Regression in Multiple Colorectal Cancer Models. J Drug Deliv. 2011;2011:869027.