Dr. Brienne Engel, shown here with her committee, successfully defended her dissertation on September 12, 2014. From left to right: Committee member Teresita Munoz-Antonia; Major Professor Doug Cress; Brienne; Defense Chair Pedro Santiago-Cardona, Ponce School of Medicine and Health Sciences; Committee members Srikumar Chellappan and Lori Hazlehurst. Dr. Engel accepted a position as Project Leader with the firm yet2.com.
Dr. Engel's publication record while in the Program:
A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma.
Chen L, Engel BE, Welsh EA, Yoder SJ, Brantley SG, Chen DT, Beg AA, Cao C, Kaye FJ, Haura EB, Schabath MB, Cress WD. J Thorac Oncol. 2016 Feb 23. pii: S1556-0864(16)00428-7.
The Retinoblastoma Tumor Suppressor Transcriptionally Represses Pak1 in Osteoblasts.
Sosa-García B, Vázquez-Rivera V, González-Flores JN, Engel BE, Cress WD, Santiago-Cardona PG. PLoS One. 2015 Nov 10;10(11):e0142406.PMID: 26555075
Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma.
Schabath MB, Welsh EA, Fulp WJ, Chen L, Teer JK, Thompson ZJ, Engel BE, Xie M, Berglund AE, Creelan BC, Antonia SJ, Gray JE, Eschrich SA, Chen DT, Cress WD, Haura EB, Beg AA.
Oncogene. 2015 Oct 19. PMID: 26477306
Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer. Cao C, Gao R, Zhang M, Amelio AL, Fallahi M, Chen Z, Gu Y, Hu C, Welsh EA, Engel BE, Haura EB, Cress WD, Wu L, Zajac-Kaye M, Kaye FJ. J Natl Cancer Inst. 2014 Dec 1;107(1):358. Print 2015 Jan. PMID:25465874
Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors. Engel BE, Welsh E, Emmons MF, Santiago-Cardona PG, Cress WD. Cell Death Dis. 2013 Nov 28;4:e938. PMID:24287699