Crystina Bronk Watson
Crystina Bronk Watson
Dr. Crystina Bronk Watson, pictured with her committee successfully defended her dissertation on November 10, 2014. From right: Committee member Shari Pilon-Thomas; Crystina; External Chair Wasif Khan from the University of Miami; Committee member Javier Pinilla-Ibarz and Major Professor Amer Beg. Not pictured: Committee member P.K. Epling-Burnette.
Immediately after graduating, Dr. Watson taught at Hillsborough Community College and participated in an internship with Moffitt's Office of Technology Management and Licensing. She has since accepted a position as a Medical Science Liaison with Eli Lilly in Boston, Mass.
Dr. Watson's Publication Record while in the Program:
HDAC inhibitors enhance T cell chemokine expression and augment response in PD-1 immunotherapy in lung adenocarcinoma. Zheng H, Zhao W, Yan C, Watson CC, Messengill M, Noyes D, Martinez GV, Afzal R, Chen Z, Ren X, Antonia SJ, Haura EB, Ruffell G, Beg AA. Clin Cancer Res. 2016 Mar 10. PMID: 26964571.
NF-kΒ is crucial in proximal T-cell signaling for calcium influx and NFAT activation. Bronk CC, Yoder S, Hopewell EL, Yang S, Celis E, Yu XZ, Beg AA. Eur J Immunol. 2014 Dec;44(12):3741-6. doi: 10.1002/eji.201444904. Epub 2014 Oct 22. PMID:25251667
Pharmacologic inhibition of PKCα and PKCΘ prevents GVHD while preserving GVL activity in mice.Haarberg KM, Li J, Heinrichs J, Wang D, Liu C, Bronk CC, Kaosaard K, Owyang AM, Holland S, Masuda E, Tso K, Blazar BR, Anasetti C, Beg AA, Yu XZ.Blood. 2013 Oct 3;122(14):2500-11. doi: 10.1182/blood-2012-12-471938. Epub 2013 Aug 1.PMID:23908466
Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells. Kim JY, Welsh EA, Oguz U, Fang B, Bai Y, Kinose F, Bronk C, Remsing Rix LL, Beg AA, Rix U, Eschrich SA, Koomen JM, Haura EB. Proc Natl Acad Sci USA 2013 July 23;110(30):12414-9. PMID: 23836654.
Lung tumor NF-kB signaling promotes T cell-mediated immune surveillance.Hopewell EL, Zhao W, Fulp WJ, Bronk CC, Lopez AS, Massengill M, Antonia S, Celis E, Haura EB, Enkemann SA, Chen DT, Beg AA.J Clin Invest. 2013 Jun;123(6):2509-22. doi: 10.1172/JCI67250. Epub 2013 May 1.PMID:23635779
Targeting PKCΘ in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential. Bronk CC, Yu XZ, Beg AA.Front Immunol. 2012 Aug 14;3:259. doi: 10.3389/fimmu.2012.00259. eCollection 2012.PMID:22912640
IKKΒ-induced inflammation impacts the kinetics but not the magnitude of the immune response to a viral vector.Hopewell EL, Bronk CC, Massengill M, Engelman RW, Beg AA.Eur J Immunol. 2012 Mar;42(3):681-7. doi: 10.1002/eji.201141910. Epub 2012 Jan 13.PMID:22161279
PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. Valenzuela JO, Iclozan C, Hossain MS, Prlic M, Hopewell E, Bronk CC, Wang J, Celis E, Engelman RW, Blazar BR, Bevan MJ, Waller EK, Yu XZ, Beg AA.J Clin Invest. 2009 Dec;119(12):3774-86. doi: 10.1172/JCI39692. Epub 2009 Nov 9.PMID:19907075