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Daniele  Gilkes

Daniele Gilkes

Daniele Gilkes

  

Bio

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Dr. Daniele Gilkes, the first USF Presidential Fellow in the Cancer Biology Program, is pictured with her Major Professor, Dr. Jiandong Chen following her successful dissertation defense on February 25, 2008. Dr. Gilkes has chosen to pursue her research at Johns Hopkins School of Medicine in the lab of Gregg Semenza, M.D., Ph.D., Director of the Program in Vascular Cell Engineering. Daniele was named the Outstanding Graduate Student at the 2007 Moffitt Scientific Retreat.

Dr. Gilkes recently accepted a position as an Assistant Professor of Oncology at the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University. She received a K99/R00 award in 2014 and had interviewed with several cancer centers prior to accepting the offer from Sidney Kimmel.

Dr. Gilkes' publication record while in the Cancer Biology Program:

Nefedova Y, Cheng P, Gilkes DM, Blaskovich M, Beg AA, Sebti SM, Gabrilovich DI. Activation of dendritic cells via inhibition of Jak2/STAT3 signaling. J Immunol 2005 Oct 1;175(7):4338-46.

Chen L, Gilkes DM, Pan Y, Lane WS, Chen J. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J. 2005 Oct 5;24(19):3411-22. Epub 2005 Sep 15.

Hu B, Gilkes DM, Farooqi B, Sebti S, Chen J. MDMX overexpression prevents P53 activation by the MDM2 inhibitor nutlin. J Biol Chem. 2006 Aug 11; [Epub ahead of print].

LeBron C, Chen L, Gilkes D, Chen J. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. EMBO Journal . 2006 Mar 22;25(6):1196-206. Epub 2006 Mar 2.

Gilkes, DM, Chen, L., and Chen, J. (2006). MDMX regulation of p53 response to ribosomal stress. Embo J 25, 5614-5625.

Hu, B., Gilkes, DM, Farooqi, B., Sebti, S. M., and Chen, J. (2006). MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. J Biol Chem 281, 33030-33035.

Hu B, Gilkes DM, Chen J. (2007) Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Res. Sep 15;67(18):8810-7.

Gilkes DM, and Chen, J. (2007). Distinct roles of MDMX in the regulation of p53 response to ribosomal stress. Cell Cycle 6, 151-155.

Gilkes DM, Pan Y, Coppola D, Yeatman T, Reuther GW, Chen J. Regulation of MDMX expression by mitogenic signaling. Mol Cell Biol. 2008 Mar;28(6):1999-2010. Epub 2008 Jan 2.

Dr. Gilkes' publication record since graduation:

Zhang H, Lu H, Xiang L, Bullen JW, Zhang C, Samanta D, Gilkes DM, He J, Semenza GL. HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells.Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6215-23. PMID: 26512116

Xiang L, Gilkes DM, Hu H, Luo W, Bullen JW, Liang H, Semenza GL. HIF-1a and TAZ serve as reciprocal co-activators in human breast cancer cells. Oncotarget. 2015 May 20;6(14):11768-78. PMID: 26059435

Xiang L, Gilkes DM, Hu H, Takano N, Luo W, Lu H, Bullen JW, Samanta D, Liang H, Semenza GL. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget. 2014 Dec 30;5(24):12509-27. PMID: 25587023

Samanta D, Gilkes DM, Chaturvedi P, Xiang L, Semenza GL. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5429-38. doi: 10.1073/pnas.1421438111. Epub 2014 Dec 1. PMID: 25453096

Hu H, Takano N, Xiang L, Gilkes DM, Luo W, Semenza GL. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 2014 Oct 15;5(19):8853-68. PMID: 25326682

Hubbi ME, Gilkes DM, Hu H, Kshitiz, Ahmed I, Semenza GL. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1a to promote cell-cycle progression. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3325-34. doi: 10.1073/pnas.1412840111. Epub 2014 Jul 28. PMID: 25071185

Wang T, Gilkes DM, Takano N, Xiang L, Luo W, Bishop CJ, Chaturvedi P, Green JJ, Semenza GL. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3234-42. doi: 10.1073/pnas.1410041111. Epub 2014 Jun 17. PMID: 24938788

Gilkes DM, Semenza GL, Wirtz D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat Rev Cancer. 2014 Jun;14(6):430-9. doi: 10.1038/nrc3726. Epub 2014 May 15. PMID: 24827502

Chaturvedi P, Gilkes DM, Takano N, Semenza GL. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2120-9. doi: 10.1073/pnas.1406655111. Epub 2014 May 5. PMID: 24799675

Gilkes DM, Xiang L, Lee SJ, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E384-93. doi: 10.1073/pnas.1321510111. Epub 2013 Dec 9. PMID: 24324133

Xiang L, Gilkes DM, Chaturvedi P, Luo W, Hu H, Takano N, Liang H, Semenza GL. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J Mol Med (Berl). 2014 Feb;92(2):151-64. doi: 10.1007/s00109-013-1102-5. Epub 2013 Nov 20. PMID: 24248265

Gilkes DM, Semenza GL. Role of hypoxia-inducible factors in breast cancer metastasis. Future Oncol. 2013 Nov;9(11):1623-36. doi: 10.2217/fon.13.92. Review. PMID: 24156323

Hubbi ME, Hu H, Kshitiz, Gilkes DM, Semenza GL. Sirtuin-7 inhibits the activity of hypoxia-inducible factors. J Biol Chem. 2013 Jul 19;288(29):20768-75. doi: 10.1074/jbc.M113.476903. Epub 2013 Jun 9. PMID: 23750001

Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res. 2013 Jun 1;73(11):3285-96. doi: 10.1158/0008-5472.CAN-12-3963. Epub 2013 Mar 28. PMID: 23539444

Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. J Biol Chem. 2013 Apr 12;288(15):10819-29. doi: 10.1074/jbc.M112.442939. Epub 2013 Feb 19. PMID: 23423382

Hubbi ME, Kshitiz, Gilkes DM, Rey S, Wong CC, Luo W, Kim DH, Dang CV, Levchenko A, Semenza GL. A nontranscriptional role for HIF-1a as a direct inhibitor of DNA replication. Sci Signal. 2013 Feb 12;6(262):ra10. doi: 10.1126/scisignal.2003417. PMID: 23405012

Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol Cancer Res. 2013 May;11(5):456-66. doi: 10.1158/1541-7786.MCR-12-0629. Epub 2013 Feb 1. PMID: 23378577

Chaturvedi P, Gilkes DM, Wong CC; Kshitiz, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest. 2013 Jan;123(1):189-205. doi: 10.1172/JCI64993. Epub 2012 Dec 17. Erratum in: J Clin Invest. 2013 Mar 1;123(3):1402. PMID: 23318994

Takano N, Sarfraz Y, Gilkes DM, Chaturvedi P, Xiang L, Suematsu M, Zagzag D, Semenza GL. Decreased expression of cystathionine ß-synthase promotes glioma tumorigenesis. Mol Cancer Res. 2014 Oct;12(10):1398-406. doi: 10.1158/1541-7786.MCR-14-0184. Epub 2014 Jul 3. PMID: 24994751

Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. J Mol Med (Berl). 2012 Jan 10.

Hubbi ME, Gilkes DM, Baek JH, Semenza GL. Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. J Biol Chem. 2012 Feb 24;287(9):6139-49.

Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16369-74.

Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT Jr, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene. 2011 Aug 22. doi: 10.1038/onc.2011.365.