Dr. Emily Hopewell, pictured above with her committee, successfully defended her dissertation on March 27, 2012. From left to right: Committee members Ken Wright and Xue-Zhong Yu; Emily Hopewell; Major Professor Amer Beg; Committee member Esteban Celis and External Chair Siddharth Balachandran, Ph.D., Fox Chase Cancer Center. Dr. Hopewell is currently employed as a Cell Therapy Development Specialist at the Moffitt Cancer Center.
Dr. Hopewell's publication record while in the Program:
Wahle JA, Paraiso KHT, Costello AL, Goll EL, Sentman CL, Kerr WG. Cutting Edge: Dominance by an MHC-Independent Inhibitory Receptor Compromises NK Killing of Complex Targets. J Immunol. 2006 Jun 15;176(12):7165-9.
Valenzuela JO, Iclozan C, Hossain MS, Prlic M, Hopewell E, Bronk CC, Wang J, Celis E, Engelman RW, Blazar BR, Bevan MJ, Waller EK, Yu XZ, Beg AA. PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. J Clin Invest. 2009 Dec;119(12):3774-86.
Wang J, Basagoudanavar SH, Wang X, Hopewell E, Albrecht R, Garc?a-Sastre A, Balachandran S, Beg AA. NF-kappaB RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication. J Immunol. 2010 Aug 1; 185(3):1720-9.
Emily L. Hopewell, Crystina C. Bronk, Michael Massengill, Robert W. Engelman, Amer A. Beg. IKKß-induced inflammation impacts the kinetics but not the magnitude of the immune response to a viral vector. European Journal of Immunology. Dec 2011.
Dr. Hopewell's publication record since graduation:
Bronk CC, Yoder S, Hopewell EL, Yang S, Celis E, Yu XZ, Beg AA. NF-?B is crucial in proximal T-cell signaling for calcium influx and NFAT activation. Eur J Immunol. 2014 Dec;44(12):3741-6. doi: 10.1002/eji.201444904. Epub 2014 Oct 22. PMID: 25251667
Wang X, Wang J, Zheng H, Xie M, Hopewell EL, Albrecht RA, Nogusa S, García-Sastre A, Balachandran S, Beg AA. Differential requirement for the IKKß/NF-kB signaling module in regulating TLR- versus RLR-induced type 1 IFN expression in dendritic cells. J Immunol. 2014 Sep 1;193(5):2538-45. doi: 10.4049/jimmunol.1400675. Epub 2014 Jul 23. PMID: 25057006
Hopewell EL, Zhao W, Fulp WJ, Bronk CC, Lopez AS, Massengill M, Antonia S, Celis E, Haura EB, Enkemann SA, Chen DT, Beg AA. Lung tumor NF-kB signaling promotes T cell-mediated immune surveillance. J Clin Invest. 2013 Jun;123(6):2509-22. doi: 10.1172/JCI67250. Epub 2013 May 1. PMID: 23635779