Dr. Je-In Youn, pictured at right, successfully defended his dissertation on January 21, 2011.
Dr. Youn completed a very successful postdoctoral fellowship in the lab of his mentor, Dr. Dmitry Gabrilovich and has recently accept a position as an assistant professor at the new Institute of Immunology, Seoul National University College of Medicine. Dr. Youn is the first Program graduate to transition from postdoc to faculty.
Dr. Youn's publication record while in the Program:
Youn J*, Nagaraj S*, Collazo M, Gabrilovich D. Subsets of Myeloid-Derived Suppressor Cells in Tumor Bearing Mice. Journal of Immunology. 2008 Oct 15;181(8):5791-802. (*equal contribution)
Zhou J, Cheng P, Youn J, Cotter M, Gabrilovich D. Notch and Wingless Signaling Cooperate in Regulation of Dendritic Cell Differentiation. Immunity. 2009 Jun 19; 30(6):845-59.
Nagaraj S, Collazo M, Corzo CA, Youn JI, Ortiz M, Quiceno D, Gabrilovich DI. Regulatory myeloid suppressor cells in health and disease. Cancer Res. 2009 Oct 1;69(19):7503-6.
Nagaraj S, Youn JI, Weber H, Iclozan C, Lu L, Cotter MJ, Meyer C, Becerra CR, Fishman M, Antonia S, Sporn MB, Liby KT, Rawal B, Lee JH, Gabrilovich DI. Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer. Clin Cancer Res. 2010 Mar 15;16(6):1812-23.
Je-In Youn, Dmitry Gabrilovich. The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity. Eur J Immunol. 2010 Nov;40(11):2969-75.
Corzo CA, Condamine T, Lu L, Cotter MJ, Youn JI, Cheng P, Cho HI, Celis E, Quiceno D, Padhya T, McCaffrey TV, McCaffrey JC, Gabrilovich DI. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J. Exp. Med. 2010 Oct 25;207(11):2439-53.
Cao M, Xu Y, Youn JI, Cabrera R, Zhang X, Gabrilovich D, Nelson DR, Liu C. Kinase inhibitor Sorafenib modulates immunosuppressive cell populations in a murine liver cancer model. Lab Invest. 2011 Apr;91(4):598-608.
Dr. Youn's publication record since graduation:
Condamine T, Ramachandran I, Youn JI, Gabrilovich DI. Regulation of tumor metastasis by myeloid-derived suppressor cells.
Annu Rev Med. 2015;66:97-110. Review. PMID: 25341012
Sahakian E, Powers JJ, Chen J, Deng SL, Cheng F, Distler A, Woods DM, Rock-Klotz J, Sodre AL, Youn JI, Woan KV, Villagra A, Gabrilovich D, Sotomayor EM, Pinilla-Ibarz J.
Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function.
Mol Immunol. 2015 Feb;63(2):579-85. PMID: 25155994
Condamine T, Kumar V, Ramachandran IR, Youn JI, Celis E, Finnberg N, El-Deiry WS, Winograd R, Vonderheide RH, English NR, Knight SC, Yagita H, McCaffrey JC, Antonia S, Hockstein N, Witt R, Masters G, Bauer T, Gabrilovich DI. ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis. J Clin Invest. 2014 Jun;124(6):2626-39. PMID 24789911
Cheng P, Kumar V, Liu H, Youn JI, Fishman M, Sherman S, Gabrilovich D. Effects of notch signaling on regulation of myeloid cell differentiation in cancer. Cancer Res. 2014 Jan 1;74(1):141-52. PMID: 24220241
Chen X, Eksioglu EA, Zhou J, Zhang L, Djeu J, Fortenbery N, Epling-Burnette P, Van Bijnen S, Dolstra H, Cannon J, Youn JI, Donatelli SS, Qin D, De Witte T, Tao J, Wang H, Cheng P, Gabrilovich DI, List A, Wei S. Induction of myelodysplasia by myeloid-derived suppressor cells. J Clin Invest. 2013 Nov;123(11):4595-611. PMID: 24216507
Nagaraj S, Youn JI, Gabrilovich DI. Reciprocal relationship between myeloid-derived suppressor cells and T cells. J Immunol. 2013 Jul 1;191(1):17-23. Review. PMID: 23794702
Youn JI, Gabrilovich DI.
New roles of Rb1 in expansion of MDSCs in cancer.
Cell Cycle. 2013 May 1;12(9):1329-30. No abstract available. PMID: 23588070
Youn JI, Kumar V, Collazo M, Nefedova Y, Condamine T, Cheng P, Villagra A, Antonia S, McCaffrey JC, Fishman M, Sarnaik A, Horna P, Sotomayor E, Gabrilovich DI. Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Nat Immunol. 2013 Mar;14(3):211-20. PMID: 23354483
Nagaraj S, Nelson A, Youn JI, Cheng P, Quiceno D, Gabrilovich DI.
Antigen-specific CD4(+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling. Cancer Res. 2012 Feb 15;72(4):928-38. PMID: 22237629
Youn JI, Collazo M, Shalova IN, Biswas SK, Gabrilovich DI. Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. J Leukoc Biol. 2012 Jan.;91(1):167-81.
Lu T, Ramakrishnan R, Altiok S, Youn JI, Cheng P, Celis E, Pisarev V, Sherman S, Sporn MB, Gabrilovich D. Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice. J Clin Invest. 2011 Oct 3;121(10):4015-29. doi: 10.1172/JCI45862.