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Douglas  Cress

Douglas Cress

Douglas Cress


Office: MRC 4072G
Phone: 813/745-6703



B.S. Virginia Polytechnic Institute and State University, Biochemistry (Summa Cum Laude) 1986
Ph.D. Michigan State University, Biochemistry 1991
Postdoc. Fellow, Duke University Medical Center, Lab of Dr. Joseph Nevins 1991-1995


My laboratory is interested in understanding in the E2F transcription factor family that is thought to be one of the key regulators of cell growth and cell death. Presently, the laboratory has two major projects.

In the first project we are using DNA chip (or microarray) technology to identify genes that are regulated by members of the E2F family. Going into this project we knew that E2F1 could activate transcription of several genes and that its expression could drive DNA synthesis and, in higher doses, cell death. Surprisingly, in our microarray experiments we found that E2F-1 expression resulted in the transcriptional repression of numerous promoters. We are further investigating the numerous E2F-regulated promoters that we have identified to determine their roles in controlling cell proliferation and cell death.

A second project revolves around a novel member of the E2F family, E2F3B, which was identified by a graduate student in the lab. Because E2F3B is most abundant in cells that are quiescent, it is our hypothesis that E2F3B has a growth restraining activity. To test this hypothesis, we are using adenovirus vectors to express E2F3B to determine it affect on cell growth control relative to other member of the E2F family.

Graduate Students