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Daniel  Sullivan

Daniel Sullivan

Daniel Sullivan
Professor

Contact

Office:
Phone: 813/745-3878
Email: Dan.Sullivan@moffitt.org

Education

B.A.: University of Louisville (Biology), 1974.
M.D.: University of Louisville School of Medicine, 1981.
M.S.: University of Louisville (Biochemistry), 1982.
Fellowship in Hematology/Oncology: Department of Medicine, University of Florida; Gainesville, FL, 1985-1988.
Internship and Residency in Internal Medicine: Department of Medicine; University of Florida, Gainesville, FL, 1982-1985.

Research

Dr. Sullivan’s laboratory is focused on defining the role of alterations in DNA topoisomerase I and II in drug resistance to inhibitors of these enzymes, more recently focusing on microenvironmental factors that modulate topoisomerase intracellular location in human myeloma and hence drug sensitivity. In addition to their normal intracellular roles, topoisomerases are also the targets of several commonly used antitumor agents-drugs used in the treatment of multiple myeloma, leukemia, breast cancer, lung cancer, ovarian cancer and lymphomas. One mechanism of drug resistance, which we have recently defined in human myeloma cells, is the trafficking of DNA topoisomerase II from the nucleus to the cytoplasm. Cells become resistant to topoisomerase II inhibitors in this case because the enzyme is no longer located where it can cause lethal DNA damage in the presence of the drug. In addition to his work in the laboratory, Dr. Sullivan has significant experience in the writing and conduct of early-phase clinical trials that have translational research components. His clinical interests are in novel approaches to treat multiple myeloma.