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Eric Haura
Professor

Contact

Office:
Phone: 813/745-6827
Email: Eric.Haura@moffitt.org

Education

Research Fellow: Department of Genetics, Laboratory of Dr. Joseph Nevins, Duke University Medical Center, October 1998 to June 2000.
Clinical Fellow: Hematology and Oncology, Duke University Medical Center, July 1997 to June 2000.
Residency: Internal Medicine, The Johns Hopkins Hospital, July 1994 to June 1997.
M.D.: Duke University School of Medicine, 1990 to 1994.
B.S.: Biomedical Engineering, The Johns Hopkins University, 1986 to 1990.

Research

Our laboratory is interested in oncogenic signal transduction pathways involved in the pathogenesis of lung cancer. The major focus of the lab has been on understanding the role of tyrosine kinase pathways and STAT signaling in lung cancer.

Ongoing projects include (1) characterizing the ability of novel inhibitors of EGFR, Src-family kinases, andStat3 signaling to suppress lung cancer cell growth with accompanying evaluation of downstream signaling pathways, (2) characterizing Stat3 and Stat1 gene expression profiles using Affymetrix gene arrays, (3) development of lung-specific Stat3 knockout mice to evaluate the requirement of Stat3 in tumor initiation and promotion, (4) determining a role for Stat3 signaling in tumor cell invasion/metastasis by examining a direct role of Stat3 in controlling genes involved in cell invasion,

Our lab also has available lung cancer tumors specimens for translational studies. This includes a tissue microarray consisting of approximately 250 NSCLC specimens with accompanying clinical data available for studies evaluating the role of various signaling pathways, a collection of tumor RNA with accompanying clinical data to evaluate prognostic roles of genes, and a collection of fresh frozen specimens available for molecular assays.