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Eric  Lau

Eric Lau

Eric Lau
Assistant Professor

Contact

Office: SRB 23344
Phone: 813/745-1302
Email: Eric.Lau@moffitt.org

Education

Ph.D.: University of California, San Diego, 2008
Postdoctoral Research Fellow: Sanford-Burnham Medical Research Institute, La Jolla, CA, 2008-2015

Research

I have worked in cancer research for more than 15 years. During my pre-doctoral training, my studies focused on determining differences in the regulation of DNA replication and cell cycle dynamics in cancer and non-cancerous human cells, and in particular, on the regulation of the pre-replication complex protein, Cdc6.

During my postdoctoral studies, my studies focused on determining the role of the transcription factor ATF2, related transcriptional regulatory and signal transduction mechanisms in melanoma. My studies uncovered a mechanism regulating the divergent oncogenic and tumor suppressor roles of ATF2 in melanoma and provided a novel function for ATF2 at mitochondria (Lau et al. Cell, 2012; Varsano and Lau et al. Clin Cancer Res, 2013).

My recent studies identified ATF2-mediated transcriptional mechanisms underlying chemoresistance (regulation of IFNB1; Lau et al. Oncogene, 2015) and metastatic capacity of melanoma (regulation of FUK; Lau et al. Sci Signal, 2015). The discovery of the role of FUK and fucosylation and their alterations in melanoma represent the basis for an unprecedented opportunity to investigate a previously unstudied area of post-translational modification and signal transduction in melanoma (and other cancers). We recently performed an unbiased mass spectrometric profiling of all fucosylated proteins in melanoma cells. These analyses highlighted signal transduction networks that are putatively impacted by fucosylation.

Based on these my laboratory research team currently focuses on elucidating the role of fucosylation in protein translation, tumor immunology, as well as cytoskeletal dynamics and how these roles contribute to the development, progression, and therapeutic resistance of melanoma.

Graduate Students

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