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Jiandong  Chen

Jiandong Chen

Jiandong Chen


Phone: 813/745-6822


Undergraduate: Department of Biology, Zhongshan University, China
Ph.D.: Department of Biological Sciences, University of Pittsburgh
Postdoc: Department of Molecular Biology, Princeton University


The major effort of our research is to elucidate how MDM2 and MDMX inhibit the tumor suppressor p53, and how stress signals activate p53. We believe that basic knowledge in this area will lead to new strategies to activate p53 in cancer cells or inhibit p53 to protect normal tissues during cancer therapy. Current work focuses on the mechanisms by which DNA damage responsive kinases such as ATM and Chk2 regulate MDM2 and MDMX conformation and ubiquitin ligase activity. The second area of our research investigates the interaction between chromatin modifying factors and the p53 pathway. We are investigating how p53 regulates histone H3 K9 methylation in constitutive heterochromatin after DNA damage, and facilitates the repair of heterochromatin DNA. The third area of research focuses on the function and regulation of SirT1. Our work suggests that SirT1 is a potential inhibitor of tumor growth. We are investigating the role of SirT1 in regulating ribosomal RNA synthesis in response to nutrient availability.

Graduate Students