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Lixin  Wan

Lixin Wan

Lixin Wan
Assistant Professor

Contact

Office: SRB 22334
Phone: 813/745-2824
Email: Lixin.Wan@moffitt.org

Links

Education

Ph.D., Biochemistry & Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences, China, 2008
Research Fellow, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2009-2012
Instructor, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2012-2015

Research

Our lab is interested in defining the molecular mechanisms of how protein post-translational modifications shape the proteomic networks and how cancer cells rewire central signaling pathways to gain proliferation advantage as well as to acquire drug resistance. The long term goal of my lab at the H. Lee Moffitt Cancer Center and Research Institute is to understand the complexity and heterogeneity of protein post-translational modifications, which will eventually lead to the identification of novel personalized cancer therapeutic strategies.

We are currently dedicated to various projects revealing the crucial roles of the Anaphase Promoting Complex and the BRAF/MEK/ERK signaling cascade in cancer development and evolution. In one of our recent publications (Wan et al. Cancer Discovery, 2017), we identified a multi-layer, reciprocal regulation between the Anaphase Promoting Complex and the BRAF kinase in melanoma. Our study thus strongly advocates for combinational treatment of melanoma patient with BRAF/MEK and CDK4/6 inhibitors. This strategy not only inhibits these oncogenic kinases, but also restores the anti-tumor function of the Anaphase Promoting Complex.

Our lab utilizes a combination of human cancer cell lines, preclinical animal models, genomic/proteomic profiling and state-of-the-art biochemical/biophysical approaches to extensively address our scientific questions.