banner USF Home College of Arts & Sciences OASIS myUSF USF A-Z Index

USF Home > College of Arts and Sciences > Cancer Biology Ph.D. Program

Michael  Mann

Michael Mann

Michael Mann
Assistant Professor

Contact

Office: SRB 23011
Phone: 813/745-1029
Email: Michael.Mann@moffitt.org

Links

Education

PhD Case Western Reserve University 2005
Cancer Research Training Award Fellow, National Cancer Institute 2005-2006
Post-doctoral Research Fellow, Institute of Molecular & Cell Biology, Singapore 2006-2008
Post-doctoral Research Associate, Institute of Molecular & Cell Biology, Singapore 2008-2011
Senior Research Associate,Houston Methodist Research Institute 2011-2015

Research

Cancer gene discovery continues to drive cancer research with the promise of identifying new diagnostic markers and targeted therapeutics by defining novel genetic events that initiate, promote or sustain tumorigenesis. The overarching goal of my lab and research programs is to integrate genetic and genomic approaches to investigate cancer driver gene function(s) during the initiation and progression of skin cancer and to understand melanocyte and keratinocyte transformation at a systems level. Applying this information in the context of human cancer will advance skin cancer research and provide the infrastructure to formulate fundamental questions in other areas of human cancer science.

To obtain a deep systems-level understanding of cutaneous cancer genomics, our work uses genetic and genomic information from unique mouse models we have developed in combination with both publicly available human cancer mutation data, and the invaluable mutation and clinical datasets and specimens available to Moffitt Cancer Center investigators. The long-term goal of my lab is to use these integrated data to design a new generation of pre-clinical mouse models for candidate cancer gene validation and to probe in vivo drug resistance mechanisms and therapeutic target gene/pathway selection with demonstrated biological importance and translational application.