banner USF Home College of Arts & Sciences OASIS myUSF USF A-Z Index

USF Home > College of Arts and Sciences > Cancer Biology Ph.D. Program

Shyam  Mohapatra

Shyam Mohapatra

Shyam Mohapatra
Professor

Contact

Office:
Phone: 813/974-8568
Email: smohapat@health.usf.edu

Education

Ph.D.: Australian National University, Canberra
Postdoctoral Fellowships: University of Bielefeld, Germany; McGill University, Montreal, Canada

Research

Current research at the Airway Disease Center is directed toward prophylactic and therapeutic modulation of upper and lower airway diseases, including respiratory syncytial virus- induced asthma and lung cancer using gene expression therapy. The lab has developed specific expertise in designing viral and non-viral vectors for gene transfer and delivering genes by novel methods into mammalian cells in vitro and in vivo. These vectors are used to test the effect of increasing or decreasing the expression in the lung of the therapeutic genes in various model systems of specific lung diseases including lung cancer. To date, the vectors used include plasmid vectors for the two classes of vaccine vectors have been designed: (1) vectors for expression of the appropriate antigen(s) and/or cytokine(s) that is (are) pivotal to protection from disease, which are delivered to lung by nanoparticle carriers, and (2) the Adenovirus and Adeno-associated virus vectors for the expression of antigens and therapeutic genes. Thus, a number of genes, including IFN-alpha, IL-12, TNF-alpha, IP-10, Lymphotactin, MIP-1beta, CD40 etc have been cloned and expressed using adenoviral gene transfer systems. Depending upon the cancer model utilized, the functional studies include immune modulation, signal transduction and apoptosis.

Specifically in relation to lung cancer, our current research focuses on the anti-cancer role of certain cytokines and chemokines on a number of tumorigenic cell lines and melanoma cell line B16, in vitro and in mouse models in vivo. Thus, recombinant Adenoviruses expressing IFN-gamma or 2'-5'oligoadenylate synthetase isoform-p-69 have been used to investigate the apoptosis of these cancer cells and the mechanism underlying apoptosis.

Current Courses

RefCourseSecCourse TitleCRDayTimeLocation
95430PHA 6119001Nanoscale Drug Delivery
3



OFFT OFF

95431PHA 6119002Nanoscale Drug Delivery
3F

1:30pm-4:00pm

MDC 2149

94127PHA 6146001Nanotechnology
Open to all students. No permit needed.
3



OFFT OFF

94529PHA 6146002Nanotechnology
Open to all students. no permit required, no restrictions
3MW

2:00pm-3:30pm

MDC 1405

86288GMS 6183001Clinical Research Methods
3



OFFT 100

96437PHA 6225002Entrepreneurship
3R

1:00pm-4:00pm

MDC 1405

95683PHA 6277001Ethics in Pharmacy Research
1



OFFT OFF

95682PHA 6277002Ethics in Pharmacy Research
1T

1:00pm-2:00pm

MDC 1405

94159PHA 6797001Scientific Writing & Comm
1



OFFT OFF

96016PHA 7930002Special Topics in Pharmacy
Conditions, Diagnostics, & Nanoscale Therapies For Research Track Students Only
1



OFFT OFF

96018PHA 7930004Special Topics in Pharmacy
Masters Thesis Capstone For Research Track Students Only
3



OFFT OFF

96019PHA 7930005Special Topics in Pharmacy
Masters Thesis Research For Research Track Students Only
5



OFFT OFF

96137PHA 7930006Special Topics in Pharmacy
Graduate Program Internship & Capstone in Pharmacy For Entrepreneurship Track
6



OFFT OFF