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Sheng  Wei

Sheng Wei

Sheng Wei
Professor

Contact

Office:
Phone: 813/745-3934
Email: Sheng.Wei@moffitt.org

Education

M.D.: Tianjin Medical University, Tianjin, China.
Postdoctoral Fellow: Univ. of South Florida, Department of Medical Microbiology and Immunology.

Research

Dr. Wei's laboratory is focused on elucidation of the signal pathway for activation of human neutrophil function by cytokines and bacterial products. He has made a key discovery that GM-CSF, IL-2 and LPS signal via src-kinase-related protein tyrosine kinase, Lyn, suggesting that Lyn is a common element in neutrophil activation. Lyn play a key role in neutrophil survival induced by GM-CSF. Use of anti-sense oligonucleotides to Lyn indicated that anti-sense Lyn could readily block GM-CSF induced neutrophil survival. Dr. Wei also identified a key role for MAP kinase in internalization and growth inhibition of C. albicans using the MAP kinase inhibitor and dominant negative MEK expression. An important discovery was that MAP kinase regulated the migration of proteolytic granules to the point of contact with C. albicans within neutrophil. Another focus is on the signals that control of Natural Killer Cell (NK) mediated tumor lysis. Analysis of signal molecules indicated that target ligation triggers a Ras-independent MAP kinase pathway that is required for lysis of the ligated tumor cells. Target engagement caused NK cells to rapidly activate MAP kinase and perforin/granzyme B polarization within NK cells towards the contacted target cells. The present effort is to further define downstream event from MAP kinase that could mediated functional activation of both human neutrophil and NK cells.