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Please click on a student's name to read about their research:
Rachel,Alyson, Neha, Meghan, Phil,Shruti, Emily,
Ani, Danielle, Michelle C., Brittany, Nicole, Cindy, Je-In, Jason,
Michael, Geoff, Lori, Jackie, David,
Kate, Crystina, Jessica, Lacy, Melissa, Valentina |
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Student Publication Record
Publications by current students:
Rios-Doria J, Fay A, Velkova A, Monteiro A. DNA damage response - Determining the Fate of Phosphorylated Histone H2AX. Cancer Biology & Therapy, 5:2, 142-144, February 2006.
Kabra N, Li Z, Chen L, Li B, Zhang X, Wang C, Yeatman T, Coppola D, Chen J. SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem. 2009 May 11.
Li Z, Chen L, Kabra N, Fang J, Chen J. Inhibition of SUV39H1 methyltransferase activity by DBC1. J Biol Chem. 2009 Feb 13.
Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y, Nemoto S,Finkel T, Gu W, Cress WD, Chen J. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol. 2006 Sep;8(9)1025-31. Epub 2006 Aug 6.
Winter SL, Wong P, Alexandrow MG. In Vivo Chromatin Decondensation Assays; Molecular Genetic Analysis of Chromatin Unfolding Characteristics of Selected Proteins. Methods Molecular Biol., 2009;523:27-40.
Wahle JA, Paraiso KHT, Costello AL, Goll EL, Sentman CL, Kerr WG. Cutting Edge: Dominance by an MHC-Independent Inhibitory Receptor Compromises NK Killing of Complex Targets. J Immunol. 2006 Jun 15;176(12):7165-9.
Collazo MM, Wood D, Paraiso KH, Lund E, Engelman RW, Le CT, Stauch D, Kotsch K, Kerr WG. SHIP limits immunoregulatory capacity in the T-cell compartment. Blood. 2009 Mar 26;113(13):2934-44. Epub 2009 Jan 9.
Thomas DeLigio, Aneliya Velkova, Diego Zorio and Alvaro N.A Monteiro. Can BRCA1 predict response to taxane-based cancer therapy. - (accepted :Anti Cancer Agents in Medicinal Chemistry) 2009.
Rios-Doria J, Velkova A, Dapic V, Galan-Caridad HM, Dapic V, Carvalho M, Melendez J and Monteiro AN. Ectopic expression of histone H2AX mutants reveal a role for its post-translational modifications. Cancer Biology and Therapy 8:5,1-13 March 2009.
Rios-Doria J, Fay A, Velkova A, Monteiro A. DNA damage response - Determining the Fate of Phosphorylated Histone H2AX. Cancer Biology & Therapy, 5:2, 142-144, February 2006.
Shain KH, Yarde DN, Meads MB, Huang M, Jove R, Hazlehurst LA, Dalton WS. Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation. Cancer Res. 2009 Feb 1;69(3):1009-15. Epub 2009 Jan 20.
Je-In Youn, Srinivas Nagaraj, Michelle Collazo, Dmitry Gabrilovich. Subsets of Myeloid-Derived Suppressor Cells in Tumor Bearing Mice. Journal of Immunology. 2008 Oct 15;181(8):5791-802.
Bewry NN, Nair RR, Emmons MF, Boulware D, Pinilla-Ibarz J, Hazlehurst LA. Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance. Mol Cancer Ther. 2008 Oct;7(10):3169-75.
Nair RR*, Emmons MF*, Cress AE, Argilagos RF, Lam K, Kerr WT, Wang HG, Dalton WS, Hazlehurst LA. HYD1-induced increase in ROS leads to autophagy and necrotic cell death in multiple myeloma cells. Accepted- Molecular Cancer Therapeutics. (* donates contributed equally to manuscript)
Dubovsky JA, McNeel DG, Powers JJ, Sotomayor EM, Pinilla-Ibarz JA. Treatment of Chronic Lymphocytic Leukemia with a Hypomethylating Agent Induces Expression of NXF2, an Immunogenic Cancer Testis Antigen. Clinical Cancer Research. 2009 Apr 28.
Pinilla-Ibarz J, Shah B, Dubovsky JA.The biological basis for immunotherapy in patients with chronic myelogenous leukemia. Cancer Control. 2009 Apr;16(2):141-52 |
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Rachel
Brunel University, United Kingdom
Major Professor:
Richard Jove, Ph.D.
Co-Major Professor:
W. Douglas Cress, Ph.D.
Research Interest:
Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors that play a role in both cytokine and growth factor signaling. STAT3 is a member of the STAT family that is transiently activated as required in normal cells, but is constitutively activated in many human tumors, causing its target genes to be continuously transcribed. STAT3 has become the subject of intense investigation as an anti-cancer therapeutic target wince the genest it turns on play a role in cell growth, proliferation, survival and angiogenesis. To date a handful of these genes have been identified, including cyclin D1, p21WAF1, Bcl-x, Mcl-1 and c-Myc. It is highly likely, however, that there are additional unidentified genes associated with STAT3 activation which, when constitutively transcribed, may play a role in oncogenesis. Therefore, the focus of my dissertation research is to identify novel STAT3-regulated genes that are important in tumor development and progression.
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Alyson
University of Massachusetts, USA
Major Professor: Alvaro Monteiro, Ph.D.
Research Interest:
My research involves characterizing interactions of proteins downstream of ATM and CHK2 in the DNA damage response pathway.
Publications:
Rios-Doria J, Fay A, Velkova A, Monteiro A. DNA damage response - Determining the Fate of Phosphorylated Histone H2AX. Cancer Biology & Therapy, 5:2, 142-144, February 2006.
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Neha
University of Delhi, India
Major Professor: Jiandong Chen, Ph.D.
Research Interest:
My project involves studying the regulation of SirT1 and its possible role in tumorigenesis. Not much is known about this gene but its homolog in yeast has been linked to longevity upon calorie restriction. If this gene had a similar role in humans, it was possible that it might be a key in promoting tumor growth despite the well-known fact that conditions within solid tumors are stressful in terms of nutrients and oxygen. I am in the process of trying different stress conditions on knock down cell lines and hope to test it in animals soon.
Publications:
Kabra N, Li Z, Chen L, Li B, Zhang X, Wang C, Yeatman T, Coppola D, Chen J. SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem. 2009 May 11.
Li Z, Chen L, Kabra N, Fang J, Chen J. Inhibition of SUV39H1 methyltransferase activity by DBC1. J Biol Chem. 2009 Feb13
Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y, Nemoto S,Finkel T, Gu W, Cress WD, Chen J. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol. 2006 Sep;8(9)1025-31. Epub 2006 Aug 6.
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Philip
"Phil"
McGill University, Canada
Major Professor: Ed Seto, Ph.D.
Research Interest:
HDAC inhibitors represent a relatively new class of anti-cancer therapeutic drug. Our lab's focus is to elucidate the molecular mechanisms underlying the functions of HDACs. I am interested in characterizing several members of the Class III HDAC family.
Publications:
Winter SL, Wong P, Alexandrow MG. In Vivo Chromatin Decondensation Assays; Molecular Genetic Analysis of Chromatin Unfolding Characteristics of Selected Proteins. Methods Molecular Biol., 2009;523:27-40.
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Shruti
University of Pune, India
Major Professor: Kenneth L. Wright, Ph.D.
Research Interest:
My research interests focus on the genetic changes during cancer development that lead to immunological alterations. I would also like to know how these alterations can be used as drug targets to help develop a possible cancer cure. This is a broad area of research and I hope to focus on a particular aspect after my first year of laboratory rotations.
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Emily
Miami University (Ohio), USA
Major Professor: Amer Beg, Ph.D.
Research Interest:
My current research focuses on modulation of dendritic cell activation through NF-κB-driven inflammation in tumor progression and promotion.
Publications:
Wahle JA, Paraiso KHT, Costello AL, Goll EL, Sentman CL, Kerr WG. Cutting Edge: Dominance by an MHC-Independent Inhibitory Receptor Compromises NK Killing of Complex Targets. J Immunol. 2006 Jun 15;176(12):7165-9.
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Aneliya
"Ani"
St. Kliment Ohridski, Sofia, Bulgaria
Major Professor: Alvaro Monteiro, Ph.D.
Research Interest:
My research is focused on the biochemical role of BRCA1 (Breast and Ovarian Cancer Susceptibility Gene 1) in DNA damage response and understanding its function in transcriptional regulation.
Publications:
Thomas DeLigio, Aneliya Velkova, Diego Zorio and Alvaro N.A Monteiro. Can BRCA1 predict response to taxane-based cancer therapy. - (accepted :Anti Cancer Agents in Medicinal Chemistry) 2009.
Rios-Doria J, Velkova A, Dapic V, Galan-Caridad HM, Dapic V, Carvalho M, Melendez J and Monteiro AN. Ectopic expression of histone H2AX mutants reveal a role for its post-translational modifications. Cancer Biology and Therapy 8:5,1-13 March 2009.
Rios-Doria J, Fay A, Velkova A, Monteiro A. DNA damage response - Determining the Fate of Phosphorylated Histone H2AX. Cancer Biology & Therapy, 5:2, 142-144, February 2006
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Danielle
University of Nebraska, USA
Major Professor: William S. Dalton, M.D., Ph.D.
Research Interest:
Currently, my research interests include studying the role of certain genes in DNA repair, cell cycle control and apoptosis. I am also interested in the effect of different types of cancer drugs on these genes and processes.
Publications:
Shain KH, Yarde DN, Meads MB, Huang M, Jove R, Hazlehurst LA, Dalton WS. Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation. Cancer Res. 2009 Feb 1;69(3):1009-15. Epub 2009 Jan 20.
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Michelle C.
Florida Institute of Technology
Major Professor: Dmitry Gabrilovich, M.D., Ph.D.
Research Interest:
My current research interests are: signal transduction pathways leading to metastasis during cancer development, formation of protein complexes involved in DNA replication or transcription in cancerous cells, the interaction between immune cells and cancerous cells and angiogenesis and cancer growth and metastasis.
Publications:
Collazo MM, Wood D, Paraiso KH, Lund E, Engelman RW, Le CT, Stauch D, Kotsch K, Kerr WG. SHIP limits immunoregulatory capacity in the T-cell compartment. Blood. 2009 Mar 26;113(13):2934-44. Epub 2009 Jan 9.
Youn J, Nagaraj S, Collazo M, Gabrilovich D. Subsets of Myeloid-Derived Suppressor Cells in Tumor Bearing Mice. Journal of Immunology. 2008 Oct 15;181(8):5791-802.
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Brittany
Denison University
Major Professor: Jiandong Chen, Ph.D.
Research Interest:
To either study the molecular basis of oncogenesis or the mechanisms of tumor recognition from immune cells and uncover the immunosuppression mechanisms that occur with tumor cells in order to develop new anti-cancer drugs.
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Nicole
Florida Atlantic University
Major Professor: Sheng Wei, M.D.
Resarch Interests:
My research interests are hematopoietic stem cell transplants and immunotherapy.
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Cindy
Rutgers University
Major Professor: Timothy Yeatman, M.D.
Research Interests:
My current research interests include immune evasion - specifically antigen presentation and alterations - in tumor cells and genetic signatures associated with early and advanced stage cancers in terms of therapeutic response and resistance.
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Je-In
Pohang University of Science & Technology
Republic of Korea
Major Professor: Dmitry Gabrilovich, M.D., Ph.D.
Research Interests:
My research interest focuses on defective dendritic cell
function in the tumor milieu.
Publications:
Youn J*, Nagaraj S*, Collazo M, Gabrilovich D. Subsets of Myeloid-Derived Suppressor Cells in Tumor Bearing Mice. Journal of Immunology. 2008 Oct 15;181(8):5791-802. (*equal contribution)
Zhou J, Cheng P, Youn J, Cotter M, Gabrilovich D. Notch and Wingless Signaling Cooperate in Regulation of Dendritic Cell Differentiation. Immunity. 2009 Jun 19; 30(6):845-59.
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Jason
University of Wisconsin, Madison
Major Professor: Eduardo Sotomayor, M.D
Co-Major Professor: Javier Pinilla, M.D., Ph.D.
Research Interests:
The association between over expression of genes, metastatic abilities of cells, and the epigenetic control of such mutations in human neoplasm.
Immunological detection and elimination of metastatic disease both natural and vaccination induced.
The application of computer science principles to biological experimentaiton and use of software and hardware to advance the abilities of scientific research.
Publications:
Dubovsky JA, McNeel DG, Powers JJ, Sotomayor EM, Pinilla-Ibarz JA. Treatment of Chronic Lymphocytic Leukemia with a Hypomethylating Agent Induces Expression of NXF2, an Immunogenic Cancer Testis Antigen. Clin Cancer Res. 2009 May 15;15(10):3406-15.
Pinilla-Ibarz J, Shah B, Dubovsky JA.The biological basis for immunotherapy in patients with chronic myelogenous leukemia. Cancer Control. 2009 Apr;16(2):141-52.
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Michael
Florida State University
Major Professor: Lori Hazlehurst, Ph.D.
Research Interests:
Combination drug therapies, Cell kill pathways, Integrin signaling.
Publications:
Bewry NN, Nair RR, Emmons MF, Boulware D, Pinilla-Ibarz J, Hazlehurst LA. Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance. Mol Cancer Ther. 2008 Oct;7(10):3169-75.
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Geoff
University of South Florida - M.S.
University of Florida - B.S.
Major Professor: Gary Reuther, Ph.D.
Research Interests:
My project involves studying the Jak family kinases. In particular, I'm looking at activating mutations in Jak1 and Tyk2, and trying to unravel the mechanisms by which they drive transformation.
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Lori
Wayne State University, B.S. & M.S.
Major Professor: Gary Reuther, Ph.D.
Research Interests:
My work involves looking at type 1 cytokine receptor signaling and key contributing mediators leading to oncogenesis in Acute Myeloid Leukemia.
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Jacqueline
"Jackie"
Ohio State University
Major Professor: Srikumar Chellappan, Ph.D.
Research Interests:
Breast cancer genetics, E2Fs, genetic pathways, role of cancer related proteins in oncogenesis.
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David
Universidad de Antioguia - Medellin
Colombia, South America
Major Professor: Dmitry Gabrilovich, M.D., Ph.D.
Research Interests:
My research interests are mechanisms of tumor evasion, modulation and impairment of the immune systems by tumor cells as well as studying how immune response effectors react against the challenge posed by tumor cells.
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Kate
University of Florida
Major Professor: Ed Seto, Ph.D.
Research Interests:
Protein Crystallography, Genetics, Immunology
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Crystina
Armstrong Atlantic State University, GA
Major Professor: Amer Beg, Ph.D.
Research Interests:
Hormones, Cell Signaling, Surface Markers of Cancer Cells
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Jessica
Marietta College, OH
Major Professor: P.K. Burnette, Ph.D.
Research Interests:
Immunology, T cells, Genetics
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Lacy
University of Wisconsin, Eau-Claire
Major Professor: Lori Hazlehurst, Ph.D.
Research Interests:
Cancer metastasis and genetic mutations that predispose
individuals to cancer development
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Melissa
University of Colorado, Boulder
Major Professor: Alvaro Monteiro, Ph.D.
Research Interests:
Drug Discovery, Genetics
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Valentina
Florida Atlantic University
Major Professor: Jie Wu, Ph.D.
Research Interests:
DNA Mutations, DNA Repair Systems, Signaling Pathways
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updated July 2008 |
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