University of South Florida

Cancer Biology Ph.D. Program at the

Keiran Smalley , Ph.D. Assistant Professor in the Department Oncologic Sciences Member-in-Residence of the Moffitt Cancer Center, Molecular Oncology Program Member of the Comprehesive Melanoma Research Center E-mail: Keiran.Smalley@moffitt.org Phone: 813-745-8725

Training
Ph.D., University of Cambridge, Cambridge, UK (2000)
Postdoctoral Fellow: University College London, UK (2000-01)
Postdoctoral Fellow: Institute of Cancer Research, London, UK (2001-03)
Staff Scientist, The Wistar Institute, Philadelphia, PA (2005-06)
Senior Scientist, The Wistar Institute, Philadelphia, PA (2006-08)

Research Interests

The aim of my research is to develop new therapies for the treatment of melanoma. We are integrating genetic and cell signaling information to identify novel subgroups of melanoma and developing novel therapeutic strategies for each of these groups. This work has a translational focus and is very much geared towards getting new compounds into clinical practice.

Search for publications by:   
This search will be conducted at the US National Library of Medicine (NLM) and PubMed.

Selected publications:

Noma, K., Smalley, K.S.M*., Lioni, M., Rustgi, A.K., El-Deiry, W., King, A.J., Herlyn, M*.: The essential role of stromal fibroblasts and the transforming growth factor (TGF)-b axis in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology 134: 1981-1993, 2008. *co-corresponding authors

Lioni, M., Noma, K., Snyder, A., El-Deiry, W., Rustgi, A., Herlyn, M., Smalley, K.S.M.: Bortezomib induces apoptosis in esophageal squamouse cell carcinoma cells via a p38 MAPK-dependent mechanism. Mol. Cancer Therap.  In Press

Smalley, K.S.M., Contractor, R., Nguyen, T.K., Xiao, M., Medina, C.A., Edwards, R., King, A.J., Flaherty, K.T., Bosenberg, M., Herlyn, M., Nathanson, K.L.: Identification of a novel sub-group of melanomas with KIT/CDK4 overexpression Cancer Res. 68: 5743-5752, 2008.

Smalley, K.S.M., Lioni, M., Dalla Palma, M., Xiao, M., Desai, B., Hansson, J., Flaherty, K.T., Herlyn, M., Nathanson, K.L.: Cyclin D1 amplification mediates resistance to BRAF inhibition in a sub-group of melanomas. Mol. Cancer Ther. In Press

Smalley, K.S.M., Xiao, M., Villanueva, J., Nguyen, T., Letrero, R., Wang, Y., Van Belle, P., Flaherty, K.T., Elder, D.E., Nathanson, K.L., Herlym, M.:  CRAF inhibition induces apoptosis in melanomas with non-BRAF V600E mutations. Oncogene In Press