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Xue-Zhong Yu, M.D.
Assistant Professor in the Department of Oncologic Sciences
Member-in-Residence, H. Lee Moffitt Cancer Center
E-mail:
Xue.Yu@moffitt.org
Phone: 813-745-3562 |
Training
M.S., Peking University, China
M.D., Peking University Health Science Center, China
Postdoctoral Fellow, Fred Hutchinson Cancer Research Center, Seattle, Washington
Research
Interests
The basic research in my laboratory concerns the T-cell response to transplantation antigen and tumor. Our efforts have focused on understanding how signals through antigen receptors and costimulatory receptors modulate T-cell activation or tolerance. The mechanisms of T-cell tolerance include deletion, anergy and immune regulation, and the aim of our research is to induce selective T-cell tolerance through these mechanisms. We hope that the insights gained from these studies can be used to develop new strategies for selective inhibition of graft-versus-host diseases (GVHD) induced by T-cells from allogeneic donor after hematopoietic cell transplantation (HCT), while leaving the graft-versus-tumor (GVT) activity intact.
Search
for publications by: 
This
search will be conducted at the US National Library of Medicine (NLM) and PubMed.
Selected
Publications
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Yu XZ, Martin PJ, Anasetti C: CD28-signal enhances apoptosis on CD8 T cells upon strong TCR ligation. J. Immunol. 170:3002, 2003.
Yu XZ, Levin SD, Madrenas J, Anasetti C: Lck required for activation-induced T-cell death after TCR ligation with partial agonists. J. Immunol. 172:1437, 2004.
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Yu XZ, Albert, MH, Martin PJ, Anasetti C: CD28 ligation induces transplantation tolerance by IFNg-depedent depletion of T cells that recognize alloantigens. J. Clin. Invest. 113:1624, 2004.
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Albert MH, Martin PJ, Anasetti C, Yu XZ: Antigen-dependent suppression of alloresponses by Foxp3-induced regulatory T cells in transplantation. Eur. J. Immunol. 35:2598, 2005.
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Yu XZ, Liang Y, Nurieva RI, Guo F, Anasetti C, Dong C: Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells. J. Immunol. 176:7394, 2006.
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